|
KMID : 1098420080160050349
|
|
Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 5 p.349 ~ p.355
|
|
|
Anticancer and Immune-modulatory Activities of Extracts from Various Parts of Cornus macrophylla Wall
|
|
Kim Young
Han Jae-Gun
Ha Ji-Hye
Jeong Hyang-Suk
Kim Cheol-Hee
Kwon Min-Cheol
Lee Hak-Ju
Kang Ha-Young
Choi Geun-Pyo
Lee Hyeon-Yong
|
|
|
Abstract
|
|
|
|
Anticancer and immuno-modulatory activities of methanol extracts from different parts, bark, wood and leaf, of Cornus macrophylla Wall. were investigated in this study. All extracts at a concentration of 1.0mg/ml showed relativity low cytotoxicities on human normal kidney cell (HEK293) by approximately 25%. Bark extract of C. macrophylla showed the highest anticancer activity on human lung cancer cell line (A549) and human breast cancer cell line (MCF-7) by 57.4% and 58.7%, respectively, at a concentration of 1.0mg/ml. All extracts enhanced the growth of human B and T cells, showing 38.7% and 65.9% increase compared to control, respectively, by 5 days incubation with bark extract. The secretions of interleukin 6 (IL6) and tumor necrosis factor alpha (TNF-) from human B and T cells were significantly increased by extracts, especially bark extract. B or T cell medium, which contains cytokines (IL 6 and TNF-) secreted by bark extract treatment for 5 days, time-dependently enhanced the growth of NK-92MI cells with the maximal effect at 5th day of incubation. These results suggest that C. macrophylla, especially bark, has the potential for anticancer and immuno-modulatory activities.
|
|
|
KEYWORD
|
|
|
Cornus macrophylla Wall., Anticancer Activity, Immune-Modulatory Activity, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|